A chemical screen identifies p38 MAPK inhibition as a candidate neuroprotective strategy for combinatorial SMA therapy
Maria Jose Carlini, Jorge Espinoza‐Derout, Meaghan Van Alstyne, Sarah Tisdale, Eileen Workman, Marina K Triplett, Ivan Tattoli, Shubhi Yadav, Christopher E. Henderson, Daniel Martin Watterson, Livio Pellizzoni
This study identifies p38 MAPK inhibition as a neuroprotective strategy that synergizes with SMN upregulation to improve motor function and survival in SMA mice.
bioRxiv · Mar 6, 2025 · PreprintNeuroscience