A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation
Virginia Busetto, Martin Brehm, Annamaria Sgromo, M. Mager, Lizaveta Pshanichnaya, Elena Becker, René F. Ketting, Stefan Ludwig Ameres, Sebastian Falk
The paper identifies MUT 15 as a pseudohelicase in the CPUG complex that remodels the nuclease module to regulate RNA cleavage and poly(UG)ylation.
bioRxiv · Sep 8, 2026 · PreprintBiochemistry