Sebastian Falk

This study shows that phosphorylation of Z granule components regulates germ granule organization and RNAi inheritance in C. elegans.

The paper identifies MUT 15 as a pseudohelicase in the CPUG complex that remodels the nuclease module to regulate RNA cleavage and poly(UG)ylation.

The paper shows that GTSF-1 binds RRF-3 in nematodes, a conserved interaction essential for 26G-RNA production and fertility.

This study identifies dual roles of ERH in primary miRNA biogenesis, showing it suppresses miRNA processing through DGCR8 binding and facilitates cluster assistance independently of this interaction.

The paper identifies an SLBP-independent mechanism for maintaining maternal histone mRNA stability in C. elegans oogenesis, mediated by the PETISCO complex and TOST-1.

The paper shows that the Drosophila Piwi-piRNA pathway silences transposons by degrading their RNA via the nuclear exosome, with TEsup proteins facilitating this process.

This study uses multiscale simulations to investigate MUT-16 phase separation and its role in recruiting MUT-8, confirming key interactions through in vitro experiments.

This study identifies two functions of the MUT7-C domain: RNA binding and recruitment to germ granules, revealing its ancestral role in MUT-7 exoribonuclease activity.

The paper identifies PUCH, a trimeric Schlafen-domain nuclease that initiates piRNA processing in C. elegans by cleaving 5-end piRNA precursors, revealing a novel RNA endonuclease mechanism.