Lizaveta Pshanichnaya

This study shows that phosphorylation of Z granule components regulates germ granule organization and RNAi inheritance in C. elegans.

The paper identifies MUT 15 as a pseudohelicase in the CPUG complex that remodels the nuclease module to regulate RNA cleavage and poly(UG)ylation.

The paper identifies a novel regulatory mechanism involving proteolytic processing of N-terminal intrinsically disordered regions in C. elegans Argonaute proteins, which controls small RNA selectivity and activity.

This study identifies two functions of the MUT7-C domain: RNA binding and recruitment to germ granules, revealing its ancestral role in MUT-7 exoribonuclease activity.