Protein synthesis is suppressed in sporadic and familial Parkinson's Disease by LRRK2
Prasannakumar Deshpande, Dani Flinkman, Ye Hong, Elena Goltseva, Valentina Siino, Lihua Sun, Sirkku A. Peltonen, Laura L. Elo, Valtteri Kaasinen, Peter James, Eleanor T. Coffey
This study shows that LRRK2 activity suppresses protein synthesis in Parkinson's disease, with inhibition restoring normal translation in patient fibroblasts.
The FASEB Journal · Sep 14, 2020Peer-reviewedNeuroscience