Author

Eliza S. Lee

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1

Frequent Co-Authors

Alexander F. PalazzoiD· 3 shared Harrison W. SmithiD· 3 shared Andrew EmiliiD· 2 shared Eric J. WolfiD· 2 shared Yifan E. WangiD· 2 shared Ayşegül Güvenek· 1 shared Bin TianiD· 1 shared Jack F. GreenblattiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Alexander F. PalazzoORCID

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3 papers

Recent·Most cited

N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs

Eliza S. Lee, Harrison W. Smith, Yifan E. Wang, Sean J. Ihn, Leticia Scalize de Olivera, Nevraj S. Kejiou, Yijing Liang, Syed Nabeel‐Shah, Robert Y. Jomphe, Shuye Pu, Jack F. Greenblatt, Alexander F. Palazzo

The paper shows that m6A modification facilitates nuclear retention of mRNAs with intact 5' splice site motifs through interactions with YTHDC1/YTHDC2, ZFC3H1, and U1-70K.

Life Science Alliance · Dec 3, 2024Peer-reviewedMolecular Biology

ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5' splice site motif within nuclear speckles

Eliza S. Lee, Harrison W. Smith, Eric J. Wolf, Ayşegül Güvenek, Yifan E. Wang, Andrew Emili, Bin Tian, Alexander F. Palazzo

The paper identifies ZFC3H1 and U1-70K as factors promoting nuclear retention of mRNAs with 5' splice site motifs in nuclear speckles through a splicing-independent mechanism.

RNA · Mar 29, 2022Peer-reviewedMolecular Biology

TPR is required for the nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes

Eliza S. Lee, Eric J. Wolf, Harrison W. Smith, Andrew Emili, Alexander F. Palazzo

The paper shows that TPR is necessary for nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes, with reporter constructs validating this role.

bioRxiv · Aug 20, 2019 · PreprintMolecular Biology