N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs
Eliza S. Lee, Harrison W. Smith, Yifan E. Wang, Sean J. Ihn, Leticia Scalize de Olivera, Nevraj S. Kejiou, Yijing Liang, Syed Nabeel‐Shah, Robert Y. Jomphe, Shuye Pu, Jack F. Greenblatt, Alexander F. Palazzo
The paper shows that m6A modification facilitates nuclear retention of mRNAs with intact 5' splice site motifs through interactions with YTHDC1/YTHDC2, ZFC3H1, and U1-70K.
Life Science Alliance · Dec 3, 2024Peer-reviewedMolecular Biology