Harrison W. Smith

This study shows that Pumilio and Brain tumor regulate Smaug mRNA degradation during the Drosophila maternal-to-zygotic transition, preventing ectopic Smaug protein expression and ensuring proper mRNA clearance.

The paper identifies a biochemical mechanism by which the MpARF1 transcription factor activates gene expression through subnuclear clustering and Mediator complex recruitment, revealing an evolutionary innovation in auxin response.

The paper shows that m6A modification facilitates nuclear retention of mRNAs with intact 5' splice site motifs through interactions with YTHDC1/YTHDC2, ZFC3H1, and U1-70K.

The paper identifies ZFC3H1 and U1-70K as factors promoting nuclear retention of mRNAs with 5' splice site motifs in nuclear speckles through a splicing-independent mechanism.

This study shows RanBP2/Nup358 enhances miRNA activity by sumoylating and stabilizing Argonaute 1, which represses IL6 mRNA translation in ANE1.

The paper shows that TPR is necessary for nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes, with reporter constructs validating this role.