Alexander F. Palazzo

The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection

This study shows that RANBP2 mutations impair its nuclear envelope localization, leading to increased influenza replication and pro-inflammatory cytokine production.

Transcription-induced mutation and ancient gBGC shape the evolution of human transcriptional start sites

The paper maps mutation patterns around human transcription start sites, revealing hypermutation and gBGC effects shaping their evolution.

Genetic and selective constraints on the optimization of gene product diversity

The paper develops a mathematical model to predict isoform abundance distributions across species and genes, finding that factors beyond selection, like population size and cis-acting loci, significantly influence evolutionary outcomes.

N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs

The paper shows that m6A modification facilitates nuclear retention of mRNAs with intact 5' splice site motifs through interactions with YTHDC1/YTHDC2, ZFC3H1, and U1-70K.

The GC-content at the 5'ends of human protein-coding genes is undergoing mutational decay

The paper investigates the evolutionary forces shaping GC-content at gene transcriptional start sites, finding that recombination patterns drive GC-content changes in mammals.

ZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5' splice site motif within nuclear speckles

The paper identifies ZFC3H1 and U1-70K as factors promoting nuclear retention of mRNAs with 5' splice site motifs in nuclear speckles through a splicing-independent mechanism.

A proximity-dependent biotinylation map of a human cell: an interactive web resource

Profiling 192 subcellular markers by proximity-dependent biotinylation (BioID) in human HEK 293 cells maps 4,145 proteins across 32 compartments via 35,902 interactions, available with analysis tools at humancellmap.org.

RanBP2/Nup358 enhances miRNA activity by sumoylating and stabilizing Argonaute 1

This study shows RanBP2/Nup358 enhances miRNA activity by sumoylating and stabilizing Argonaute 1, which represses IL6 mRNA translation in ANE1.

TPR is required for the nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes

The paper shows that TPR is necessary for nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes, with reporter constructs validating this role.

Pyruvate Kinase M Links Glucose Availability to Protein Synthesis

The paper shows that PKM inhibits translation of 7% of the transcriptome under high glucose and pyruvate conditions by stalling ribosome elongation, linking glycolysis to protein synthesis and cell cycle regulation.