Syed Nabeel‐Shah

Integrative analysis reveals extensive interactions among C2H2 zinc finger proteins at chromatin loop anchors

The paper identifies extensive interactions among C2H2 zinc finger proteins at chromatin loop anchors using ChIP-seq, interactome data, and chromatin interaction maps.

ZNF121 recruits YTHDF2 to modulate mRNA stability

The paper identifies ZNF121 as a cofactor that enhances YTHDF2-mediated mRNA decay by facilitating its binding to target transcripts, thereby modulating mRNA stability and cell-cycle regulation.

Regulation of transcription termination by FUS and TDP-43

This study shows that TDP-43 and FUS are recruited by the R1810me2s-SMN pathway, and their defects affect RNAPII termination and R-loop accumulation, contributing to neurodegenerative disorders.

N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5' Splice Site Motifs

The paper shows that m6A modification facilitates nuclear retention of mRNAs with intact 5' splice site motifs through interactions with YTHDC1/YTHDC2, ZFC3H1, and U1-70K.

Recruitment of the m6A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48

This study identifies ZBTB48 as a regulator of FTO's substrate selectivity by facilitating its binding to m6A/m6Am-containing RNAs, affecting RNA decay and cancer cell growth.

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs

This study identifies SARS-CoV-2 N protein interactions with host proteins and mRNAs, showing it attenuates stress granule formation and alters gene expression.

KRAB Zinc Finger protein Znf684 interacts with Nxf1 to regulate mRNA export

The paper identifies Znf684 as a C2H2-ZnF protein that interacts with Nxf1 and regulates mRNA export by binding to specific mRNAs.

Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila

The paper identifies RebL1 as an orthologue of human RBBP4/7 in Tetrahymena thermophila, showing its role in epigenetic regulation and oncogenic functions across species.