Chromosomal instability increases radiation sensitivity
Pippa F. Cosper, Maha Paracha, Kathryn M. Jones, Laura Hrycyniak, Les Henderson, Ava Bryan, Diego Eyzaguirre, Emily McCunn, Elizabeth Boulanger, Jun Wan, Kwangok P. Nickel, Vanessa L. Horner, Rong Hu, Paul M. Harari, Randall J. Kimple, Beth A. A. Weaver
The paper shows that higher chromosomal instability (CIN) in cancer cells and tumors increases sensitivity to radiation, both directly and through drug-induced CIN mechanisms.
International Journal of Radiation Oncology*Biology*Physics · Jan 21, 2026Peer-reviewedCancer Biology