Paul M. Harari

This paper develops a novel syngeneic mouse model for HNSCC to study immune evasion and evaluates its response to immunotherapies.

This paper develops a patient-specific microphysiological system to predict chemoradiation response in head and neck cancer by reconstructing tumor microenvironment complexity.

The paper shows that higher chromosomal instability (CIN) in cancer cells and tumors increases sensitivity to radiation, both directly and through drug-induced CIN mechanisms.

This study identifies context-dependent myeloid-T cell interactions in HNSCC ICB response using integrated single-cell and spatial omics data.