Roderick E. Hubbard

P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity

This paper shows P-Rex1 limits agonist-induced GPCR internalisation through its PDZ, DEP, and IP4P domains, independent of its Rac-GEF activity, by inhibiting phosphorylation and interacting with Grk2.

Expanding the scope of a catalogue search to bioisosteric fragment merges using a graph database approach

This paper introduces a graph database approach to expand fragment merging by incorporating bioisosteric substructures, improving computational efficiency and chemical diversity in drug design.

The use of a graph database is a complementary approach to a classical similarity search for identifying commercially available fragment merges

The paper uses a graph database to identify fragment merges from chemical catalogues, finding complementary results to traditional similarity searches.