Spatial and Cellular Architecture of the Glioblastoma Microenvironment Associated with Tumor-Infiltrating Lymphocyte Expansion
Kelly M. Hotchkiss, Kenan Zhang, Anna M. Corcoran, Elizabeth Owens, Jodie Jepson, Kyra Van Batavia, Pamela Noldner, Katayoun Ayasoufi, Kirit Singh, Michael C. Brown, Beth H. Shaz, Jose Ramon Conejo-Garcia, John W. Hickey, Mustafa Khasraw
The paper examines TIL expansion in glioblastoma by analyzing spatial organization and myeloid context, finding that TIL+ tumors have distinct immune interactions and vascular niches.
bioRxiv · Mar 26, 2025 · PreprintCancer Biology