Kelly M. Hotchkiss

This study shows that IL-12-secreting CAR-T cells improve glioblastoma treatment by enhancing T-cell persistence and reprogramming the tumor microenvironment without lymphodepletion.

This study shows that virus-specific CD8 T cells are generated and reactivated in the bone marrow after brain viral infections, leading to changes in the bone marrow niche.

This study shows that IL-7-expanded autologous lymphocytes increase VLA-4 expression and accumulate in glioblastoma tumors, enhancing the effectiveness of T cell-based therapies.

The paper examines TIL expansion in glioblastoma by analyzing spatial organization and myeloid context, finding that TIL+ tumors have distinct immune interactions and vascular niches.