Katayoun Ayasoufi

IL-12 Secreting CAR-T Cells Reprogram the Tumor Microenvironment and Improve Efficacy Against Heterogeneous Models of Glioblastoma

This study shows that IL-12-secreting CAR-T cells improve glioblastoma treatment by enhancing T-cell persistence and reprogramming the tumor microenvironment without lymphodepletion.

Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche

This study shows that virus-specific CD8 T cells are generated and reactivated in the bone marrow after brain viral infections, leading to changes in the bone marrow niche.

Temporal single-cell profiling uncovers age-associated delays in immune resolution to respiratory viral infection

This study identifies age-associated delays in immune resolution to respiratory viral infection by analyzing single-cell RNA sequencing and flow cytometry data from young and aged mice.

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

Measles vaccine attenuation comprises innate immune cell infection and interferon responses

This study identifies that measles vaccine attenuation involves enhanced infection of innate immune cells and strong interferon responses that limit viral replication.

Induced Proteinuria Enhances Adeno-Associated Virus Transduction of Renal Tubule Epithelial Cells After Intravenous Administration

The paper shows that inducing proteinuria enhances viral vector transduction of renal tubule epithelial cells after intravenous administration.

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models

This study shows that IL-7-expanded autologous lymphocytes increase VLA-4 expression and accumulate in glioblastoma tumors, enhancing the effectiveness of T cell-based therapies.

Spatial and Cellular Architecture of the Glioblastoma Microenvironment Associated with Tumor-Infiltrating Lymphocyte Expansion

The paper examines TIL expansion in glioblastoma by analyzing spatial organization and myeloid context, finding that TIL+ tumors have distinct immune interactions and vascular niches.

Deficiency of Hv1 Proton Channel Enhances Macrophage Antigen Presentation and Anti-Tumor Responses in Glioma

This study shows that reducing Hv1 proton channels in macrophages improves antigen presentation and anti-tumor responses in glioma by altering macrophage behavior and immune response.

Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis

The paper identifies UDP-P2Y6 signaling as a key driver of microglial calcium activity, phagocytosis, and neuroinflammation during epileptogenesis.

TREM2 mediates MHCII-associated CD4+ T cell response against gliomas

The paper shows that higher TREM2 expression in gliomas correlates with poor prognosis, but TREM2 deficiency does not improve outcomes in pre-clinical models, as it impairs myeloid cell phagocytosis and MHCII-dependent CD4+ T cell responses.

Antigen presentation by discrete class I molecules on brain endothelium dynamically regulates T-cell mediated neuropathology in experimental cerebral malaria

This study shows that specific MHC class I molecules on brain endothelium regulate CD8 T cell activity and neuropathology in experimental cerebral malaria.