Regulating IL-2 immune signaling function via a core allosteric structural network
Claire H. Woodward, Shahlo O. Solieva, Daniel H. Hwang, Viviane S. De Paula, Charina S. Fabilane, Michael C. Young, Tony Trent, Ella C. Teeley, Ananya K. Majumdar, Jamie B. Spangler, Gregory R. Bowman, Nikolaos G. Sgourakis
This paper investigates how dynamic structural networks in IL-2 superkines affect receptor binding and signaling, showing that modulating core dynamics can improve immune cell selectivity.
Journal of Molecular Biology · Jan 1, 2024Peer-reviewedBiochemistry