Author

Michael C. Young

Children's Hospital of PhiladelphiaORCID 0000-0002-8420-2149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel H. HwangiD· 2 shared Nikolaos G. SgourakisiD· 2 shared Ananya K. MajumdariD· 1 shared Charina S. FabilaneiD· 1 shared Claire H. WoodwardiD· 1 shared Dimitri S. MonosiD· 1 shared E. John WherryiD· 1 shared Ella C. Teeley· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Daniel H. HwangORCID

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2 papers

Recent·Most cited

Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies

Hoang Anh T. Phan, Soomin Eom, Daniel Hwang, Michael C. Young, Shirley M. Sun, Molly C. Erdman, Yi Sun, Leena Mallik, Photis Rotsides, Mark M. Painter, E. John Wherry, Dimitri S. Monos, Nikolaos G. Sgourakis

The paper introduces VLP-Open HLA nanoparticles for high-throughput T cell screening, enabling efficient peptide exchange and antigen-specific T cell activation.

Science Advances · Jun 12, 2026Peer-reviewedImmunology

Regulating IL-2 immune signaling function via a core allosteric structural network

Claire H. Woodward, Shahlo O. Solieva, Daniel H. Hwang, Viviane S. De Paula, Charina S. Fabilane, Michael C. Young, Tony Trent, Ella C. Teeley, Ananya K. Majumdar, Jamie B. Spangler, Gregory R. Bowman, Nikolaos G. Sgourakis

This paper investigates how dynamic structural networks in IL-2 superkines affect receptor binding and signaling, showing that modulating core dynamics can improve immune cell selectivity.

Journal of Molecular Biology · Jan 1, 2024Peer-reviewedBiochemistry