The G protein inhibitor YM-254890 is an allosteric glue
Tony Trent, Justin J. Miller, Kendall Blumer, Gregory R. Bowman
The paper investigates how YM-254890 specifically inhibits Gq/11 by stabilizing the G-Gβγ complex through allosteric effects, revealing its mechanism as an 'allosteric glue'.
Journal of Molecular Biology · Mar 13, 2025Peer-reviewedBiophysics