Ellie Thacker

BzAM terpolymer series with a step-wise systematic change in hydrophobicity, provides a nuanced platform for functional analysis of GPCRs in native-like nanodiscs

This paper introduces a series of BzAM terpolymers with varying hydrophobicity to solubilize GPCRs in nanodiscs, showing that solubilization efficiency and functional integrity are preserved.

Sulfo-DIBMA encapsulation uniquely preserves signalling-competent active states of class B1 GPCRs, CGRP and PTH1 receptors, in native-like nanodiscs

This paper shows that sulfo-DIBMA nanodiscs preserve active-state signaling of class B1 GPCRs better than other copolymers, enabling functional studies of these receptors.