Joseph Gunner

BzAM terpolymer series with a step-wise systematic change in hydrophobicity, provides a nuanced platform for functional analysis of GPCRs in native-like nanodiscs

This paper introduces a series of BzAM terpolymers with varying hydrophobicity to solubilize GPCRs in nanodiscs, showing that solubilization efficiency and functional integrity are preserved.

Sulfo-DIBMA encapsulation uniquely preserves signalling-competent active states of class B1 GPCRs, CGRP and PTH1 receptors, in native-like nanodiscs

This paper shows that sulfo-DIBMA nanodiscs preserve active-state signaling of class B1 GPCRs better than other copolymers, enabling functional studies of these receptors.

The effect of oxidative stress on the Adenosine A2a Receptor structure, activity and signalling

This study investigates how oxidative stress affects the structure, activity, and signaling of the Adenosine A2a Receptor (A2aR), finding no structural impact but increased cAMP levels in response to agonists under oxidative conditions.