Dmitry B. Veprintsev

Sulfo-DIBMA encapsulation uniquely preserves signalling-competent active states of class B1 GPCRs, CGRP and PTH1 receptors, in native-like nanodiscs

This paper shows that sulfo-DIBMA nanodiscs preserve active-state signaling of class B1 GPCRs better than other copolymers, enabling functional studies of these receptors.

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay.

This paper develops a TR-FRET-based assay to measure ligand binding kinetics for CB1R and CB2R, finding that D77 enables accurate determination of on- and off-rates for various agonists and antagonists.

Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f

The paper determines the cryo-EM structure of mTAAR7f bound to DMCH, revealing its unique binding site and activation mechanism distinct from ORs.

Combined docking and machine learning identifies key molecular determinants of ligand pharmacological activity on β2 adrenoceptor.

The paper uses docking and machine learning to identify molecular interactions that determine agonist or antagonist activity of β2 adrenoceptor ligands.

Cell-to-cell variations in subcellular localisation of V2R are independent of its expression level

The paper shows that cell-to-cell variations in V2R subcellular localization are independent of expression levels and influenced by cell-specific environments.