Farhaan Napier Khwaja

This paper introduces a series of BzAM terpolymers with varying hydrophobicity to solubilize GPCRs in nanodiscs, showing that solubilization efficiency and functional integrity are preserved.

This study compares the functional and structural properties of the intracellular agonist PCO371 with the extracellular peptide agonist PTH 1-34 at the PTH1R, revealing PCO371's non-biased signaling profile and lower potency.

This paper shows that sulfo-DIBMA nanodiscs preserve active-state signaling of class B1 GPCRs better than other copolymers, enabling functional studies of these receptors.