The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes
Mary E.W. Collier, Georgia Ceeney, Joshua Chiappelli, Korrapati V. Sathyasaikumar, Thong Huy Cao, Paulene Quinn, Junfeng Ma, Aashti Shauriq, Nicolas B. Sylvius, Edward J. Hollox, Donald J. L. Jones, Andrew Hudson, Elliot L. Hong, Nigel Shaun Scrutton, Robert M. Schwarcz, Flaviano Giorgini
This study investigates the functional impact of SNPs rs1053230 and rs2275163 on KMO protein stability and interactions, linking rs1053230 to depressive mood symptoms.
bioRxiv · May 21, 2026 · PreprintMolecular Biology