Danny J.J. Wang

Distinct spatial organization of human hippocampal perfusion and microvascular pulsatility across age

The paper maps human hippocampal perfusion and microvascular pulsatility across age using MRI and integrates these with histological and transcriptomic data, revealing distinct spatial organization and age-related differences.

Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex

The paper introduces CCSI, a metric linking cortical blood flow and cellular architecture, showing its correlation with metabolic and structural features across brain regions.

Lifespan Trajectories of the Brains Functional Complexity Characterized by Multiscale Sample Entropy

This study analyzes fMRI-complexity trajectories across the lifespan using multiscale sample entropy and finds a nonlinear peak in brain complexity around age 23, with gender differences and associations with executive function.

Alteration of Water Exchange Rates Following Focused Ultrasound-Mediated BBB Opening in the Dorsal Striatum of Non-Human Primates: A Diffusion-Prepared pCASL Study

This study uses DP-pCASL to measure BBB water exchange rates before and after FUS-mediated BBB opening in non-human primates, finding localized decreases and global increases in Kw.

Arousal increases locus coeruleus blood flow, salience-related brain responses, and modulates negative-valence attentional biases

This study shows that arousal increases locus coeruleus blood flow and modulates brain responses to negative-valence stimuli, while the amygdala shows valence-general responses.

Factor Analysis of Multimodal MRI, Biofluid and Vascular Health Biomarkers Reveals Latent Constructs of Brain Health

The paper uses factor analysis on multimodal biomarkers to identify latent constructs of brain health, finding five distinct constructs associated with age and cognitive function.

Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study

This study examines relationships between MRI-based measures of neurovascular integrity and fluid transport in older adults, finding age-related changes and stable inter-relationships among these metrics.

Age-Related Decline in Blood-Brain Barrier Function is More Pronounced in Males than Females in Parietal and Temporal Regions

The paper investigates age and sex differences in BBB function using MRI in 186 participants, finding more pronounced decline in males starting in the early 60s, particularly in parietal and temporal regions.

Vessel Density Mapping of Cerebral Small Vessels on 3D High Resolution Black Blood MRI

This paper introduces a pipeline for mapping cerebral small vessel density using 3D black-blood MRI, finding higher density in young subjects and correlations with cognitive scores in aged subjects.

FMRI complexity correlates with tau-PET in Late-Onset and Autosomal Dominant Alzheimer's Disease

The paper correlates rs-fMRI complexity, measured by entropy, with tau-PET in Alzheimer's disease, showing associations with cognitive decline mediated through tau accumulation.

Laminar perfusion imaging with zoomed arterial spin labeling at 7 Tesla

This paper introduces a 3D zoomed arterial spin labeling technique at 7T to quantitatively measure laminar cerebral blood flow in human brain regions during rest and task activation.

Layer-dependent multiplicative effects of spatial attention on contrast responses in human early visual cortex

This study investigates how spatial attention affects contrast responses across different cortical layers in human early visual cortex using high-resolution fMRI.

Differences in high-definition transcranial direct current stimulation over the motor hotspot versus the premotor cortex on motor network excitability

This study compares the effects of high-definition tDCS over the motor hotspot and premotor cortex on motor network excitability, finding greater responsiveness and fMRI complexity changes with premotor stimulation.