Elliott Somerville

Naked antisense oligonucleotides access the cytosol during early endocytic trafficking

This study tracks antisense oligonucleotides (ASOs) through endocytic trafficking, finding that productive escape occurs early in endosomes before sequestration in late compartments.

Tau seeding in neurons enabled by transient endolysosomal perforations are confined within endolysosomes

This study shows that tau seeding in neurons occurs via transient endolysosomal perforations that remain confined within endolysosomes and require PIKfyve activity.

Close-Up of vesicular ER Exit Sites by Volume Electron Imaging using FIB-SEM

The paper uses FIB-SEM and ASEM to identify and characterize vesicular ER exit sites in mammalian cells, revealing their abundance and organization.

Depletion of endomembrane reservoirs drives phagocytic appetite exhaustion in macrophages

This study identifies endomembrane depletion as a key factor in phagocytic capacity exhaustion in macrophages.