Induction of the ISR by AB5 subtilase cytotoxin drives IFN-I expression in pDCs via STING activation
Daniela Barros, Beatriz H. Ferreira, Paulina A García-González, Francesco Carbone, Marine Luka, Fátima Leite-Pinheiro, Mariana D. Machado, Theopisti Nikolaou, Angelo Pilotti, Emily Goguet, Paulo Antas, Andreia V. Mendes, Lichen Zhang, Marina Cresci, Lou Galliot, , Philippe Pierre
The paper shows SubAB induces IFN-I in pDCs via STING activation and UPR, highlighting a novel mechanism of immune regulation.
Proceedings of the National Academy of Sciences · May 19, 2025Peer-reviewedImmunology