Philippe Pierre

SNUPR enables single-cell UPR profiling and reveals the role of IRE-1 axis in predicting bortezomib resistance in multiple myeloma.

The paper shows STING dampens the unfolded protein response to allow self-antigen presentation on MHC-I during inflammation, linking it to immune regulation in Parkinson's disease.

VPS34-IN1 inhibits cap-mediated translation and enhances STING-driven type-I IFN expression in human plasmacytoid DCs by altering SGK3 recruitment and STING degradation.

The paper shows SubAB induces IFN-I in pDCs via STING activation and UPR, highlighting a novel mechanism of immune regulation.

The paper examines metabolic profiles of circulating plasmacytoid dendritic cells (pDCs) in systemic sclerosis (SSc) patients, finding differences based on clinical phenotypes.

This study identifies and characterizes the functional roles of microproteins (sPEPs) in three human tissues, revealing two distinct functional groups and their regulatory roles.

MetamORF compiles and normalizes unique short ORFs from human and mouse genomes using experimental and computational methods, enabling new analyses of sORF functions.