VPS34-IN1 inhibits cap-mediated translation and synergizes with STING to drive type-I IFN expression in human plasmacytoid DCs
Paulo Antas, Mariana D. Machado, Fátima Leite-Pinheiro, Daniela Barros, Carlota Ramalhinho, Andreia V. Mendes, Beatriz H. Ferreira, Daniela Claudino Carvoeiro, Luís F. Mendes, Marisa Reverendo, Iola F. Duarte, Miwako Narita, Bing Su, Rafael José Argüello, Béatrice Nal, , Evelina Gatti
VPS34-IN1 inhibits cap-mediated translation and enhances STING-driven type-I IFN expression in human plasmacytoid DCs by altering SGK3 recruitment and STING degradation.
Cellular & Molecular Biology Letters · Jan 24, 2026Peer-reviewedImmunology