Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of MAPT Mutation iPSC-derived Neurons
Lianna D’Brant, Natasha Rugenstein, Su Kyoung Na, Michael J. Miller, Timothy F. Czajka, Nicole Trudeau, Emily M Fitz, Lindsay Tomaszek, Elizabeth S. Fisher, Ethan Mash, Shona Joy, Steven Lotz, Susan M. Borden, Katherine Stevens, Susan K. Goderie, , David C. Butler
The paper develops fully human bifunctional anti-tau intrabodies that reduce intracellular tau and improve neuronal survival in disease-associated mutations.
bioRxiv · May 28, 2024 · PreprintNeuroscience