Author

Natasha Rugenstein

Neural Stem Cell Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

David C. Butler· 2 shared Lianna D’Brant· 2 shared Michael J. MilleriD· 2 shared Timothy F. CzajkaiD· 2 shared Adam Tully WaickmaniD· 1 shared Ava R. JarvisiD· 1 shared Celeste M M. KarchiD· 1 shared Céline HardyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

David C. Butler

Mutual co-authors in cluster

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2 papers

Recent·Most cited

HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer's Disease

Emmanuel C. Ijezie, Michael J. Miller, Céline Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D’Brant, Natasha Rugenstein, Adam Tully Waickman, Eain A. Murphy, David C. Butler

This study shows HSV-1 infection alters MAPT splicing, increases 4R-Tau protein and hyperphosphorylation, and promotes Tau pathology in neural models.

Brain Pathology · Mar 26, 2025Peer-reviewedMicrobiology

Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of MAPT Mutation iPSC-derived Neurons

Lianna D’Brant, Natasha Rugenstein, Su Kyoung Na, Michael J. Miller, Timothy F. Czajka, Nicole Trudeau, Emily M Fitz, Lindsay Tomaszek, Elizabeth S. Fisher, Ethan Mash, Shona Joy, Steven Lotz, Susan M. Borden, Katherine Stevens, Susan K. Goderie, , David C. Butler

The paper develops fully human bifunctional anti-tau intrabodies that reduce intracellular tau and improve neuronal survival in disease-associated mutations.

bioRxiv · May 28, 2024 · PreprintNeuroscience