Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice
Karel Aceituno, Katrina Granger, Jocelyne Leon, José A. Godoy-Lugo, Khristina E. Young, Tiarra Joseph, Kailin Liu, Iris Daphne Kruijff, Emily Morales, Mia Hakian, Allison Birnbaum, Rik van der Kant, Cristal M. Hill, Constanza J. Cortés
This study shows that long-term voluntary exercise in 5xFAD mice leads to limited molecular changes in the hippocampus that do not translate into significant neuroprotection.
bioRxiv · Sep 24, 2026 · PreprintNeuroscience