Author

Iris Daphne Kruijff

Amsterdam Neuroscience

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Rik van der KantiD· 2 shared Adrian M. IsaacsiD· 1 shared Alessandro Ori‬‬iD· 1 shared Alexander J. CammackiD· 1 shared Allison BirnbaumiD· 1 shared Ashling GibliniD· 1 shared Christina E. ToomeyiD· 1 shared Constanza J. CortésiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Rik van der KantORCID

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Author profile →

2 papers

Recent·Most cited

Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice

Karel Aceituno, Katrina Granger, Jocelyne Leon, José A. Godoy-Lugo, Khristina E. Young, Tiarra Joseph, Kailin Liu, Iris Daphne Kruijff, Emily Morales, Mia Hakian, Allison Birnbaum, Rik van der Kant, Cristal M. Hill, Constanza J. Cortés

This study shows that long-term voluntary exercise in 5xFAD mice leads to limited molecular changes in the hippocampus that do not translate into significant neuroprotection.

bioRxiv · Sep 24, 2026 · PreprintNeuroscience

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4

Femke M. Feringa, Sascha Koppes-den Hertog, Lian Y. Wang, Rico J. E. Derks, Iris Daphne Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg, Damien Olivier‐Jimenez, Lill Eva Johansen, Alexander J. Cammack, Ashling Giblin, Christina E. Toomey, , Rik van der Kant

The paper introduces the Neurolipid Atlas, a lipidomics resource for neurodegenerative diseases, revealing that ApoE4 impairs astrocyte reactivity by promoting cholesterol ester accumulation.

Nature Metabolism · Sep 22, 2025Peer-reviewedNeuroscience