Diverse Microbial Exposure Enhances CD8+ T Cell Effector Memory Output and Function
Claire E. Thefaine, Erin D. Lucas, Katharine E. Block, Mark J. Pierson, Emma M. Dehm, Matthew A. Huggins, Odhran Casey, David Zemmour, Stephen C. Jameson, Sara E. Hamilton, the immgenT project
The paper compares T cell landscapes in mice with normalized microbial exposure (NME) and specific pathogen-free (SPF) conditions, finding increased effector memory CD8+ T cells in NME mice.
bioRxiv · Feb 4, 2026 · PreprintImmunology