Stephen C. Jameson

STEVE evaluates cell-type annotation robustness in scRNA-seq datasets through subsampling, novel cell detection, and benchmarking against ground-truth labels.

The paper compares T cell landscapes in mice with normalized microbial exposure (NME) and specific pathogen-free (SPF) conditions, finding increased effector memory CD8+ T cells in NME mice.

This study identifies Noxa's role in metabolic reprogramming to glutamine dependence in CD8+ T cells, independent of its canonical apoptotic function, and suggests its potential as an immunotherapeutic target.

This study shows that IL-7 and IL-15 collaborate to support memory CD8+ T cells, with IL-7R required for self-renewal and IL-15 imposing dependence on IL-7R.

The paper investigates how IL-4 from therapeutic or helminth-induced sources affects bystander activation of CD8 T cells, showing it modulates cytotoxic mediator expression without fully blocking the process.

ZipSeq maps single-cell transcriptomes in real-time within intact tissues, revealing new gene expression patterns and differentiation trajectories in various biological contexts.