Mark J. Pierson

The paper uses fibroblasts from 86 mammalian species to study virus-host susceptibility and innate immune responses across diverse mammals.

This study shows that dirty mice, with broad microbial exposure, better model human immune responses to SARS-CoV-2 mRNA vaccines, showing reduced antibody titers and faster waning compared to SPF mice.

The paper compares T cell landscapes in mice with normalized microbial exposure (NME) and specific pathogen-free (SPF) conditions, finding increased effector memory CD8+ T cells in NME mice.

The paper shows that malaria-experienced individuals have NK cells producing more IL-10, which may reduce inflammation and protect against malaria symptoms.