Author

Katharine E. Block

University of MinnesotaORCID 0000-0001-9488-3577Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

David ZemmouriD· 3 shared Odhran Casey· 3 shared Aaron C. LiuiD· 2 shared Alexander V. ChervonskyiD· 2 shared Alexandra CassanoiD· 2 shared Alia Welsh· 2 shared Ananda W. GoldrathiD· 2 shared Andrea Lebron Figueroa· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

David ZemmourORCID

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4 papers

Recent·Most cited

Diverse Microbial Exposure Enhances CD8+ T Cell Effector Memory Output and Function

Claire E. Thefaine, Erin D. Lucas, Katharine E. Block, Mark J. Pierson, Emma M. Dehm, Matthew A. Huggins, Odhran Casey, David Zemmour, Stephen C. Jameson, Sara E. Hamilton, the immgenT project

The paper compares T cell landscapes in mice with normalized microbial exposure (NME) and specific pathogen-free (SPF) conditions, finding increased effector memory CD8+ T cells in NME mice.

bioRxiv · Feb 4, 2026 · PreprintImmunology

Genomic Specificity of Anti-TCR mAbs determined by single-cell RNAseq

Ian Magill, Val Piekarsa, Σοφία Κοσσίδα, Joshua D. Croteau, Amy Huei‐Yi Lee, ROBERT S. BALDERAS, David Zemmour, Christophe O. Benoist, immgenT Project, Aaron C. Liu, Alexander V. Chervonsky, Alexandra Cassano, Alia Welsh, Ananda W. Goldrath, Andrea Lebron Figueroa, , Xutong Gong

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

The Journal of Immunology · Aug 1, 2025Peer-reviewedImmunology

Expansion of mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

Abigail A. Jaquish, Eleni Phung, Xutong Gong, Pilar Baldominos, Silvia Galván-Peña, Ian Magill, Isabelle Bursulaya, Eleonora Marina, Aaron C. Liu, Alexander V. Chervonsky, Alexandra Cassano, Alia Welsh, Ananda W. Goldrath, Andrea Lebron Figueroa, Ankit Malik, , Deepshika Ramanan

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

Nature Immunology · Jul 29, 2025Peer-reviewedImmunology

Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells

Nicholas N. Jarjour, Talia S Dalzell, Nicholas Joseph Maurice, Kelsey Marie Wanhainen, Changwei Peng, Stephen D. O’Flanagan, Taylor A. DePauw, Katharine E. Block, William J. Valente, Katherine Maude Ashby, David Masopust, Stephen C. Jameson

This study shows that IL-7 and IL-15 collaborate to support memory CD8+ T cells, with IL-7R required for self-renewal and IL-15 imposing dependence on IL-7R.

Immunity · Feb 28, 2025Peer-reviewedImmunology