Author

Sara E. Hamilton

University of MinnesotaORCID 0000-0002-3768-7622Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Claire E. ThefaineiD· 2 shared David ZemmouriD· 2 shared Erin D. LucasiD· 2 shared Mark J. PiersoniD· 2 shared Odhran Casey· 2 shared the immgenT project· 2 shared Alexander V. ChervonskyiD· 1 shared Ananda W. GoldrathiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Claire E. ThefaineORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

Ian Magill, Odhran Casey, Dania Mallah, Siba Smarak Panigrahi, Leon Lee Zhou, Olga Barreiro del Río, Derek J. Bangs, Gavyn Chern Wei Bee, Samantha M. Borys, Josh Choi, Can Ergen, Enxhi Ferraj, Maurizio Fiusco, Antoine Freuchet, Giovanni Galletti, , the immgenT project

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

bioRxiv · Sep 2, 2026 · PreprintImmunology

Diverse Microbial Exposure Enhances CD8+ T Cell Effector Memory Output and Function

Claire E. Thefaine, Erin D. Lucas, Katharine E. Block, Mark J. Pierson, Emma M. Dehm, Matthew A. Huggins, Odhran Casey, David Zemmour, Stephen C. Jameson, Sara E. Hamilton, the immgenT project

The paper compares T cell landscapes in mice with normalized microbial exposure (NME) and specific pathogen-free (SPF) conditions, finding increased effector memory CD8+ T cells in NME mice.

bioRxiv · Feb 4, 2026 · PreprintImmunology

Phenotype and function of IL-10 producing NK cells in individuals with malaria experience.

Sarah A. McNitt, Jenna K. Dick, María Andrea Hernández-Castañeda, Jules A. Sangala, Mark J. Pierson, Marissa G. Macchietto, Kristina S. Burrack, Peter D. Crompton, Karl B. Seydel, Sara E. Hamilton, Geoffrey T. Hart

The paper shows that malaria-experienced individuals have NK cells producing more IL-10, which may reduce inflammation and protect against malaria symptoms.

JCI Insight · May 7, 2025Peer-reviewedImmunology