Troriluzole Rescues Glutamatergic Deficits, Amyloid and Tau Pathology, and Synaptic and Memory Impairments in 3xTg-AD Mice
Jeremiah C. Pfitzer, Priyanka D. Pinky, Savannah Perman, Emma Redmon, Luca Cmelak, Vishnu D. Suppiramaniam, Vladimir Coric, Irfan Qureshi, Michael W. Gramlich, Miranda N. Reed
This study shows troriluzole reduces glutamate release and cognitive deficits in 3xTg-AD mice by targeting presynaptic changes linked to AD pathology.
Journal of Neurochemistry · Aug 30, 2024Peer-reviewedPharmacology & Toxicology