Inhibition of haao-1 enhances oxidative stress response by activating hormetic redox signaling in C. elegans.
Raúl Castro-Portuguez, Kayla M. Raymond, Emma Thullen, Alana M. Hendrickson, Samuel Freitas, Bradford Hull, Jeremy Meyers, Niall Thorns, Emily A. Gardea, Hope T. L. Dang, Luis S. Espejo, George L. Sutphin
The paper shows that inhibiting haao-1 in C. elegans enhances oxidative stress resistance by activating the Nrf2/SKN-1 pathway through a hormetic redox mechanism.
bioRxiv · Feb 16, 2023 · PreprintMolecular Biology