Antibody feedback limits specific B-cell entry and alters germinal center repertoires by antibody-antigen complexes
Keisuke Tonouchi, Joel Finney, Emmanuel James San, Elizabeth S. Van Itallie, Joshua S. Martin Beem, Dongmei Liao, Xiaoe Liang, Ling Yuan, Scott E. Szafranski, Masayuki Kuraoka, Kevin R. McCarthy, Kevin J. Wiehe, Stephen C. Harrison, Garnett H. Kelsoe
The paper shows that passive antibody feedback reduces RBS-specific GC B cells and increases unspecific B cells, with no effect on primary GC response magnitude.
bioRxiv · Aug 4, 2026 · PreprintImmunology