Stephen C. Harrison

This study uses cryogenic electron tomography to visualize the mechanism of membrane perforation during rhesus rotavirus entry, linking structural data with live-cell imaging.

The paper shows that passive antibody feedback reduces RBS-specific GC B cells and increases unspecific B cells, with no effect on primary GC response magnitude.

This study shows that a conventional H1 HA trimer vaccine elicits stem-directed antibodies in rhesus macaques that provide broad protection against H1N1 and H5N1 influenza.

The paper reports structures of folding intermediates of beta-barrel proteins assembled by BAM, showing a uniform folding mechanism across diverse substrates.

The paper shows that phosphorylation of Stu2 by Cdc5 and dephosphorylation by PP2ACdc55 regulate its localization from kinetochores to microtubules during anaphase.

The paper develops fluorescence-barcoded cell lines expressing membrane-anchored influenza neuraminidases to study antibody responses and vaccine efficacy.

The paper determines the cryo-EM structure of immature, small VLPs of dengue virus type 2, revealing octahedral symmetry and prM-E heterodimer clustering, with implications for vaccine design.

The paper determines the structure of infectious VSV particles using cryo-EM and computational classification, revealing the organization of the RNP and matrix proteins in the viral shaft and tip.

This paper presents the structure of the rabies virus polymerase complex determined by electron cryo-microscopy, revealing its pre-initiation conformation and differences from elongation states.

The paper reports the structure of vesicular stomatitis virus L protein in complex with its phosphoprotein cofactor, revealing how P induces a closed conformation for RNA synthesis.

The paper determines the in situ structure of rotavirus VP1 RNA-dependent RNA polymerase using local reconstruction, showing conformational changes during transcription and stochastic distribution of VP1 molecules.