Elizabeth S. Van Itallie

B Cell Receptor Signaling Sets Boundaries for Selection of Broadly Neutralizing Antibody Functional Mutations

The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.

Antibody feedback limits specific B-cell entry and alters germinal center repertoires by antibody-antigen complexes

The paper shows that passive antibody feedback reduces RBS-specific GC B cells and increases unspecific B cells, with no effect on primary GC response magnitude.

Rapid vaccine induction of macaque HIV-1 V2 Apex broadly neutralizing antibodies with immunogenetic signatures that are potentially translatable to humans

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.

Iterative immunogen optimization to focus elicited responses on a conserved, subdominant influenza hemagglutinin epitope

The paper designs immunogens that redirect immune responses to a conserved influenza epitope using iterative machine learning and in vivo testing.

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

This study shows a novel two-step mechanism for inducing broadly neutralizing HIV antibodies in macaques using a modified SHIV, informing vaccine design.

Transitions in the proteome and phospho-proteome during early embryonic development in Xenopus

The paper analyzes proteome and phospho-proteome changes during Xenopus embryonic development, identifying key transitions in protein expression and phosphorylation patterns.

Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

This study uses phosphoproteomics to analyze protein phosphorylation during Xenopus oocyte meiotic divisions, revealing key phosphorylation events and their roles in meiotic processes.

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

Wnt11 family dependent morphogenesis during frog gastrulation is marked by the cleavage furrow protein anillin

The paper investigates the role of Wnt11 family proteins in frog gastrulation, showing that their loss disrupts blastopore closure and endoderm internalization through effects on cell contractility and morphology.

Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg

The paper quantifies protein and phospho-site dynamics during fertilization and meiotic exit in Xenopus eggs using mass spectrometry-based proteomics, revealing limited degradation and extensive dephosphorylation.