Early life γδT cell activation enforces intestinal barrier integrity during intergenerational C. difficile colonization
Bavanitha Thurairajah, Susan Westfall, Lisa Chiggiato, Liam Keogh, Anshul Sinha, Kaitlin A. Olsen, Christina Gavino, Yohannes Tafesse, Emmanuelle Moens, Patrick Lypaczewski, Ghislaine Fontès, B. Jesse Shapiro, Benoit Cousineau, Samantha Gruenheid, David Vermijlen, , Irah L. King
The paper identifies a microbiota-dependent type 3 immune response in mice during weaning that involves γδ T cells, which limit C. difficile growth and maintain intestinal barrier integrity.
bioRxiv · May 1, 2026 · PreprintImmunology