Gen Lin

The paper uses single-nucleus RNA-seq to analyze cerebrovascular transcriptomic changes in Alzheimer's Disease and primary tauopathies, identifying shared heat-shock responses and disease-specific vascular remodeling.

The paper analyzes endothelial cell heterogeneity across brain regions in Alzheimer's disease using single nucleus RNAseq, revealing region-specific gene expression changes and disease-related transcriptomic alterations.

The paper identifies mRNA stability regulation as a factor modulating transcriptional memory in yeast, showing it enhances gene expression remodelling in primed cells.

This study uses single-nucleus RNA-sequencing to analyze astrocyte transcriptomic changes across the spatiotemporal progression of Alzheimer's disease, revealing gene expression trajectories and heterogeneity.

The paper investigates the in vivo localization of Msh5 during meiosis in yeast, showing its association with DSB hotspots, chromosome axis, and centromeres, and its role in promoting crossover formation.