Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistance
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim, Mayur Sharma, Johnny C. Akers, Thien Phuc Nguyen, Eric Wong, Margot Martinez-Moreno, Efrosini Kokkoli, Shobha Vasudevan, Sean Edward Lawler, Wafik S. El‐Deiry, Ziya L. Gokaslan, Clark C. Chen
The paper shows that miR-181d degradation via a PNPT1-ATR feed-forward loop increases MGMT expression variance, leading to temozolomide resistance in glioblastoma cells.
bioRxiv · Apr 22, 2025 · PreprintCancer Biology