Author

Johnny C. Akers

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Clark C. CheniD· 1 shared Efrosini KokkoliiD· 1 shared Eric Wong· 1 shared Gatikrushna SinghiD· 1 shared Iteeshree MohapatraiD· 1 shared Margot Martinez-MorenoiD· 1 shared Mayur Sharma· 1 shared Sean Edward LawleriD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Clark C. ChenORCID

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1 paper

Recent·Most cited

Modulating populational variance of methyl-guanine methyl transferase expression through miR-181d degradation: a novel mechanism of temozolomide resistance

Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim, Mayur Sharma, Johnny C. Akers, Thien Phuc Nguyen, Eric Wong, Margot Martinez-Moreno, Efrosini Kokkoli, Shobha Vasudevan, Sean Edward Lawler, Wafik S. El‐Deiry, Ziya L. Gokaslan, Clark C. Chen

The paper shows that miR-181d degradation via a PNPT1-ATR feed-forward loop increases MGMT expression variance, leading to temozolomide resistance in glioblastoma cells.

bioRxiv · Apr 22, 2025 · PreprintCancer Biology