Macrophage-derived CCL24 promotes fibrosis and worsens cardiac dysfunction during heart failure
Preethy Parthiban, Fanta Barrow, Haiguang Wang, Upendra Chalise, Natalia Araujo, Fernando Souza-Neto, Huy Nguyen, Micah Draxler, Jean Pierre Pallais, Doğacan Yücel, Hong Liu, Erin Ciske, Patrick Fehrenbach, Andrew N. Hakeem, Sang Hun Lee, , Xavier S. Revelo
This study shows that macrophage-derived CCL24 worsens fibrosis and cardiac dysfunction in heart failure by activating fibroblasts through the CCR3 receptor.
Circulation Research · Sep 16, 2025Peer-reviewedImmunology