Author

Huy Nguyen

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Genetic & Genomic Medicine· 4 Cancer Biology· 1 Immunology· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 5 Approach:experimental assay· 4 Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2

Frequent Co-Authors

Benjamin M. NealeiD· 4 shared Mark J. DalyiD· 4 shared Matthew SolomonsoniD· 4 shared Amy Trankiem· 3 shared Brooke WolfordiD· 3 shared Juha M KarjalaineniD· 3 shared Karolina ChwiałkowskaiD· 3 shared Kumar VeerapeniD· 3 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Benjamin M. NealeORCID

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Author profile →

8 papers

Recent·Most cited

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Shuhei Asada, Guangli Zhu, Jithma P. Abeykoon, Yutaro Tanaka, Huy Nguyen, Yuna Hirohashi, Divya Iyer, Nicholas William Ashton, Sirisha Mukkavalli, Martha Velazquez, Lige Jiang, Miles D. Del Busso, Judith Jebastin Thangaiah, Steven Ian Robinson, Kalindi Parmar, , Alan D. D’Andrea

This paper shows that Ewing sarcoma cells have reduced POLθ expression and MMEJ activity due to EWS-FLI1 or EWSR1 disruption, making them sensitive to inhibitors of FA, NHEJ, or HR pathways.

Molecular Cell · Jul 21, 2026Peer-reviewedCancer Biology

Novel bile salt analogs reduce lipid accumulation in liver cells with potential to treat both metabolic dysfunction-associated steatotic liver disease and Clostridioides difficile infection

Defeng Cai, Huy Nguyen, Yang Zhang, S T Bahade A S Lanje and S J Sharma S T Bahade A S Lanje and S J Sharma, Angel Schilke, Rola Raychouni, Efren Heredia, Ernesto Abel‐Santos, Steven M. Firestine, W.T. Liu

The paper screens bile salt analogs to identify compounds that reduce lipid accumulation in liver cells and inhibit C. difficile spore germination, offering potential dual therapy for MASLD and CDI.

bioRxiv · Jun 16, 2026 · PreprintPharmacology & Toxicology

CHAMP1 Complex Promotes Heterochromatin Assembly and Reduces Replication Stress

Feng Li, Amira Elbakry, Felix Y. Zhou, Tianpeng Zhang, Ramya Ravindranathan, Huy Nguyen, Aleem Syed, Lifang Sun, Sirisha Mukkavalli, Roger A. Greenberg, Alan D. D’Andrea

This study identifies the CHAMP1 complex as a regulator of heterochromatin assembly and replication fork stability, showing its role in preventing genomic instability in cancer cells.

Proceedings of the National Academy of Sciences · Jan 2, 2026Peer-reviewedMolecular Biology

Macrophage-derived CCL24 promotes fibrosis and worsens cardiac dysfunction during heart failure

Preethy Parthiban, Fanta Barrow, Haiguang Wang, Upendra Chalise, Natalia Araujo, Fernando Souza-Neto, Huy Nguyen, Micah Draxler, Jean Pierre Pallais, Doğacan Yücel, Hong Liu, Erin Ciske, Patrick Fehrenbach, Andrew N. Hakeem, Sang Hun Lee, , Xavier S. Revelo

This study shows that macrophage-derived CCL24 worsens fibrosis and cardiac dysfunction in heart failure by activating fibroblasts through the CCR3 receptor.

Circulation Research · Sep 16, 2025Peer-reviewedImmunology

Systematic single-variant and gene-based association testing of thousands of phenotypes in 426,370 UK Biobank exomes

Konrad J. Karczewski, Matthew Solomonson, Katherine R. Chao, Julia K. Goodrich, Grace Tiao, Wenhan Lu, Bridget M. Riley-Gillis, Ellen A. Tsai, Hye In Kim, Xiuwen Zheng, Fedik Rahimov, Sahar Esmaeeli, A. Jason Grundstad, Mark Reppell, Jeff Waring, , Benjamin M. Neale

The paper performs single-variant and gene-based association analyses of 4,529 phenotypes using exome data from 426,370 UK Biobank individuals, finding associations linked to variant frequency and deleteriousness.

Cell Genomics · Aug 15, 2022Peer-reviewedGenetic & Genomic Medicine

Mapping the human genetic architecture of COVID-19: an update

COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak, Juha M Karjalainen, Christine R. Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Writing group, Writing group lead, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Analysis group, Manuscript analyses team lead, , David Morrison

This study updates the genetic architecture of COVID-19 by adding 11 new genome-wide significant loci through a large GWAS meta-analysis.

Nature · Aug 3, 2022Peer-reviewedGenetic & Genomic Medicine

Insights into genetic factors contributing to variability in SARS-CoV-2 susceptibility and COVID-19 disease severity

Matteo D’Antonio, Jennifer Nguyen, Timothy D. Arthur, Hiroko Matsui, Agnieszka D’Antonio‐Chronowska, Kelly A. Frazer, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Christine R. Stevens, G. K. Pathak, Shea J. Andrews, Masahiro Kanai, Mattia Cordioli, Juha M Karjalainen, , Rasoul Aliannejad

This study identifies genetic loci associated with SARS-CoV-2 susceptibility and disease severity using GWAS and colocalization, and links them to eQTLs in various tissues.

Cell Reports · Nov 1, 2021Peer-reviewedGenetic & Genomic Medicine

Mapping the human genetic architecture of COVID-19 by worldwide meta-analysis

Mari Niemi, Juha M Karjalainen, Rachel G. Liao, Benjamin M. Neale, Mark J. Daly, Ganna Andrea, Gita A. Pathak, Shea J. Andrews, Kanai Masahiro, Kumar Veerapen, Israel Fernández‐Cadenas, Eva C. Schulte, Pasquale Striano, Minttu Marttila, Camelia Minica, , Bahareh Sedaghati-khayat

This study identifies 13 genome-wide significant loci associated with SARS-CoV-2 infection or severe COVID-19 through a global meta-analysis of 49,562 patients.

Research at the University of Copenhagen (University of Copenhagen) · Jan 1, 2021Peer-reviewedGenetic & Genomic Medicine