Doğacan Yücel

This study shows that macrophage-derived CCL24 worsens fibrosis and cardiac dysfunction in heart failure by activating fibroblasts through the CCR3 receptor.

This study identifies molecular mechanisms of cardiomyocyte aging using single-nucleus RNA-seq, ATAC-seq, and epigenetic analyses in mice, revealing DNA methylation and ESRRG as key regulators.

The paper identifies Endoglin as an inhibitor of cardiomyocyte proliferation and shows its role in cardiac regeneration through genetic and mechanistic studies.

This paper describes a method to generate high-purity, scalable human iPSC-derived cardiomyocytes using a bioreactor, showing improved viability, function, and consistency compared to traditional methods.

The paper develops small molecule inhibitors of MEIS1 that modulate HSC activity and show efficacy in vitro and in vivo.